High dilutions of homeopathic remedies induce relaxation of rat aorta precontracted with Noradrenalin
Keywords: High dilution drug, isolated aorta, hypertension, noradrenalin,
AbstractBACKGROUND Homeopathic potencies have been reported to produce alteration of contraction in isolated rat ileum in an organ bath. Potentized homeopathic drugs like Lycopus V and Aurum met are used for the treatment of hypertension. AIM The purpose of this study is to see whether Lycopus V 30 CH and Aurum met 30 CH could produce relaxation of isolated rat aorta in the organ bath. METHODS The aorta of rats were dissected out, placed in Krebs-Henseleit solution, cleared of connective tissue and endothelium and cut into 2-2.5 mm long rings. The rings were fixed in organ baths with the upper end connected by a string to an isometric transducer which was finally attached through a data acquisitation equipment to a computer. Aurum met 30 CH Lycopus V 30 CH, and their medium 90% ethanol were added separately to the bathing fluid containing the aorta rings which were precontracted with noradrenalin (NA). RESULTS Both the drugs produced significant relaxation of the aorta (p<0.001) precontracted with NA (10-7 M). The control did not show any marked effect on the NA induced contraction of aorta. CONCLUSION A potentised drug is thought to be specifically structured water which can transform the water structure in the bathing fluid and the isolated tissue immersed in the fluid into its own form. This in turn produces the observed relaxation. Both Lycopus V 30 CH and Aurum met 30 CH are effective in reducing NA induced contraction of rat aorta. Drugs can directly act on the isolated rat aorta without any system of influence. KEY WORDS High dilution drug, isolated aorta, hypertension, noradrenalin.
Basic Research (Biology)