Anxiolytic effect of the homeopathic complex Tepeex®


  • Jose Carlos Tavares Carvalho Universidade Federal do Amapá
  • Raiza Marques Vieira Campos Universidade Federal do Amapá
  • Aline Ferreira Vaz Universidade Federal do Amapá
  • Kélem Costa dos Santos Universidade Federal do Amapá
  • Ezequiel Paulo Viriato Faculdade de Ciéncias Farmacéuticas e Bioquímicas Oswaldo Cruz


Anxiety, homeopathic complex, pre-clinical model, rats,


Aims: Homeopathic complex Tepeex® is a compound of Actaea racemosa 4cH, Natrum muriaticum 2cH, Pulsatilla nigricans 3cH, Chamomilla 3cH and Sepia succus5cH. This study evaluated the effect of Tepeex® in pre-clinical models of depression and anxiety. Methods: the following tests were performed: elevated plus maze test (EPM); forced swimming test (FST); open field test (OFT) and Rotarod test (RRT). Results: In EPM, animals treated with Tepeex® on days 20 and 30 stayed longer in the open arms of the maze than the control group (p < 0.05, Dunnett test). In FST, treatment with Tepeex® did not increase swimming time compared to the control group in any phase of treatment. In OFT, crossing increased significantly with treatment with amfepramone, and also with 30-day treatment with Tepeex® (p < 0.05, Dunnette test). In RRT, treatment with amfepramone significantly reduced latency time. 30-day treatment with Tepeex® did not affect motor coordination when compared to the control group. Conclusion: results suggest that homeopathic complex Tepeex® has anxiolytic properties without affecting motor coordination.

Author Biographies

Jose Carlos Tavares Carvalho, Universidade Federal do Amapá

Lp>PhD, Research Laboratory of Drugs, Federal University of Amapá, Brazil

Raiza Marques Vieira Campos, Universidade Federal do Amapá

Laboratório de Pesquisa em Fármacos

Aline Ferreira Vaz, Universidade Federal do Amapá

Laboratório de Pesquisa em Fármacos

Kélem Costa dos Santos, Universidade Federal do Amapá

Laboratório de Pesquisa em Fármacos






Basic Research (Biology)

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