Anxiolytic effect of the homeopathic complex TepeexÃƒâ€šÃ‚Â®
Keywords:Anxiety, homeopathic complex, pre-clinical model, rats,
AbstractAims: Homeopathic complex TepeexÃƒâ€šÃ‚Â® is a compound of Actaea racemosa 4cH, Natrum muriaticum 2cH, Pulsatilla nigricans 3cH, Chamomilla 3cH and Sepia succus5cH. This study evaluated the effect of TepeexÃƒâ€šÃ‚Â® in pre-clinical models of depression and anxiety. Methods: the following tests were performed: elevated plus maze test (EPM); forced swimming test (FST); open field test (OFT) and Rotarod test (RRT). Results: In EPM, animals treated with TepeexÃƒâ€šÃ‚Â® on days 20 and 30 stayed longer in the open arms of the maze than the control group (p < 0.05, Dunnett test). In FST, treatment with TepeexÃƒâ€šÃ‚Â® did not increase swimming time compared to the control group in any phase of treatment. In OFT, crossing increased significantly with treatment with amfepramone, and also with 30-day treatment with TepeexÃƒâ€šÃ‚Â® (p < 0.05, Dunnette test). In RRT, treatment with amfepramone significantly reduced latency time. 30-day treatment with TepeexÃƒâ€šÃ‚Â® did not affect motor coordination when compared to the control group. Conclusion: results suggest that homeopathic complex TepeexÃƒâ€šÃ‚Â® has anxiolytic properties without affecting motor coordination.
<a rel="license" href="http://creativecommons.org/licenses/by-nc-sa/4.0/"><img alt="Creative Commons License" style="border-width:0" src="https://i.creativecommons.org/l/by-nc-sa/4.0/88x31.png" /></a><br />This work is licensed under a <a rel="license" href="http://creativecommons.org/licenses/by-nc-sa/4.0/">Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License</a>.