Effect of Zincum metallicum and LPS treatments on femoral bone density in pregnant mice
Keywords:perinatal, BALB/C, mice, Zincum metallicum, LPS, bone, femur, density, dimorphism
AbstractBackground: The simulated bacterial infection is a classical experimental model, by the injection of purified gram negative bacteria wall lipopolysaccharide (LPS) which produces effects similar to real infection, but without presence of the microorganism. The LPS is a stress factor as during the pregnancy and delivery, and pilot experiments have shown that ultra-high dilutions (UHD) may have a beneficial role in reducing the LPS stress. Zincum metallicum (Zm) has a potential to influence several physiological aspects of a living organism. It was chosen by a team of researchers from GIRI, to explore the effect of Zm on various experimental model (Zincum project). The optical density is a radiographic method for the measurement of the amount of hard bone tissue, and is an accessible, simple and non-invasive method. It is hypothesized that UHD Zm may influence the Zinc metabolism, therefore, bone tissues were collected to evaluate the zinc concentration.
Copyright (c) 2015 Silvio Leite Monteiro da Silva, Maristela Dutra Correa, Claudio Costa, Vanessa Gallego Arias Pecorari, Emiko Saito Arita, Maria Martha Bernardi, Carla Holandino, Leoni Villano Bonamin
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