International Journal of High Dilution Research - ISSN 1982-6206 https://www.highdilution.org/index.php/ijhdr <div style="width: 100%; text-align: justify; font-size: 12px;">IJHDR is a full submission free / open-access electronic journal specialized in the multidisciplinary field of High Dilution (HD) research. Hosted by GIRI (https://giri-society.org/) and supported by HRI (https://www.hri-research.org/), it is double-blinded peer-reviewed, counting on an international editorial board, and published quarterly. The journal id indexed at LILACS/BIREME/PAHO/WHO and EBSCO and inserted at SCOPUS, Qualis-CAPES, Latindex, OJS/PKP, Google Scholar, DOAJ, NSDL/NSF, Open J-Gate, JournalSeek, and BVS.</div> <div style="width: 100%; text-align: justify; font-size: 12px;">IJHDR counts on the services of ABEC and Crossref. Eventual plagiarism is checked by the iThenticate service.</div> <div style="width: 100%; text-align: justify; font-size: 12px;">IJHDR adopts the ethical standards described by the Committee on Publication Ethics (COPE) and the<br />International Committee of Medical Journal Editors (ICMJE).</div> Groupe International de Recherche sur l'Infinitesimal - GIRI en-US International Journal of High Dilution Research - ISSN 1982-6206 1982-6206 <p>&lt;a rel="license" href="http://creativecommons.org/licenses/by-nc-sa/4.0/"&gt;&lt;img alt="Creative Commons License" style="border-width:0" src="https://i.creativecommons.org/l/by-nc-sa/4.0/88x31.png" /&gt;&lt;/a&gt;&lt;br /&gt;This work is licensed under a &lt;a rel="license" href="http://creativecommons.org/licenses/by-nc-sa/4.0/"&gt;Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License&lt;/a&gt;.</p> <!-- <p>Upon acceptance of an article for publication, author(s) recognize Groupe International de Recherche sur l'Infinitésimale (GIRI) as the <strong>Licensor</strong>. International Journal of High Dilution Research (IJHDR) has adopted Creative Commons Public License (CCPL) as CC-by-nc-nd.</p><a href="http://creativecommons.org/licenses/by-nc-nd/3.0/" rel="license"><img style="border-width:0" src="http://i.creativecommons.org/l/by-nc-nd/3.0/80x15.png" alt="Creative Commons License" align="absMiddle" /></a> Licensed to <a href="http://www.giriweb.com" rel="GIRI">GIRI </a>under <a href="http://creativecommons.org/licenses/by-nc-nd/3.0/" rel="license">CCPL</a>. <p>Under this license, others are allowed to download your article from IJHDR website and share it with others as long as they mention authors and licensor as well as link back to IJHDR, but they cannot change it any way nor can use it for commercial purposes.</p><p>More information at: <a href="http://creativecommons.org/licenses/by-nc-nd/3.0/legalcode">http://creativecommons.org/licenses/by-nc-nd/3.0/legalcode</a></p> --> Promotion of Growth, Chlorophyll Content and Yield of Rice by a New Drug at Ultra High Dilution https://www.highdilution.org/index.php/ijhdr/article/view/1061 Application of synthetic fertilizers reduces natural fertility of soil and contaminates ground water. Some photosynthesis inhibitors at ultra-high dilution (UHD) increase photosynthesis, growth and yield of crops. A weedicide Paraquat at UHD enhanced growth and yield of potatoes in fields. This weedicide was serially diluted with distilled water and manually succussed in 30 steps following the method of preparation of homeopathic dilutions called potencies. In this way the 30th potency of Paraquat called Paraquat 30cH was prepared and preserved in 90 % ethanol. Paraquat 30cH was diluted with water 1:1000 (v/v) and sprayed on rice plants in a field measuring 0.3125 acre. The control plot of the same area was situated 300 meters away from the test plot. Three treatments were given at an interval of 7 days. Treated plot showed increased growth, chlorophyll content and yield of rice significantly as compared to control. The UHD of the weedicide produced exactly the opposite effect of the crude material on plants. The increased growth and yield of rice by Paraquat 30cH may be due to enhancement of photosynthesis of treated plants. The UHD of Paraquat increased yield of rice by 19.35% over the control. Priya Mondal Siddharthasankar Banerjee Nirmal Chandra Sukul Raj Kumar Singh Indrani Chakraborty Anirban Sukul Copyright (c) 2021 Priya Mondal, Siddharthasankar Banerjee, Nirmal Chandra Sukul, Raj Kumar Singh, Indrani Chakraborty, Anirban Sukul https://creativecommons.org/licenses/by-nc-sa/4.0 2021-07-22 2021-07-22 20 2-3 16 23 10.51910/ijhdr.v20i2-3.1061 Homeopathic repertorization in vegetables: a case study for the bell pepper culture (Capsicum annuum L, Solanaceae) https://www.highdilution.org/index.php/ijhdr/article/view/1089 <p><strong>Abstract: </strong>Background Anamnesis and homeopathic repertorization are important steps for the collection of symptoms and for the selection of the suitable medicine to cure vegetables presenting pathologies or changes in homeostasis. Aims The objective of this study was to carry out observation, anamnesis and homeopathic repertorization of bell pepper plants and its cultivation environment and select the <em>simillimum</em> medicine for the culture. Methods The study was performed at the Research and Extension Center in Agroecology of Ressacada Experimental Farm - Center of Agrarian Sciences, Federal University of Santa Catarina (UFSC) in Florianópolis, Brazil.&nbsp; The selection of symptoms were based on the characteristics &nbsp;of the diseases observed in the plants and modalized by evidenced characteristics in the environment. Symptoms were chosen by the mechanical method without hierarchization, and without a master &nbsp;symptom, and after their analogy with the symptoms described in the Homeopathic Materia Medica. Results The choice for <em>Calcarea carbonica</em> and <em>Sulphur</em> drugs was based on the number of covered symptoms and the score obtained during the digital repertorization performed by the software HomeoPro®. The chosen potency, 30 CH, was based on the miasmatic magnitude presented by the symptoms. Conclusion The analogy of symptoms found in the agricultural organism with the symptoms described in the Homeopathic Materia Medica presents a promising path for choosing medicine for the cure of diseases in vegetables. The choice of the appropriate homeopathic medicine for agricultural crops must represent the symptomatic totality presented by the plant and by the environment in the homeopathic repertorization.</p> Patrizia Bricarello Edaciano Leandro Lösch Copyright (c) 2021 Patrizia Bricarello, Edaciano Leandro Lösch https://creativecommons.org/licenses/by-nc-sa/4.0 2021-07-22 2021-07-22 20 2-3 24 33 10.51910/ijhdr.v20i2-3.1089 A Review on Anxiety Disorders During Covid-19 Pandemic: https://www.highdilution.org/index.php/ijhdr/article/view/1066 The unprecedented Covid-19 pandemic has created havoc in most areas of human lives. Anxiety disorders are most prevalent and disabling psychiatric disorders and the incidence is increased in this scenario. Homeopathy is an established system of medicine with evidence base on effectiveness in mental health issues. There is a dearth of literature concerning the potential utility of Homoeopathy in the management of psychological issues during this pandemic. This overview is aimed to find out the commonly prevalent anxiety disorders and to assess the usefulness of homoeopathic medicines in the management of anxiety through selective literature search of articles and available research studies in homoeopathy on anxiety. In conclusion, mental health is a critical concern in a pandemic's scenario and Homoeopathy can be a safe and effective alternative or adjunctive to the conventional system in the management of anxiety disorders during this chaotic situation. Deepthi Gilla Jaseel Ahammed Akhila AL Sreelakshmy SR Copyright (c) 2021 Deepthi Gilla, Jaseel Ahammed, Dr, Akhila AL, Dr, Sreelakshmy SR, Dr https://creativecommons.org/licenses/by-nc-sa/4.0 2021-07-22 2021-07-22 20 2-3 75 85 10.51910/ijhdr.v20i2-3.1066 Effects of Bacillus firmus e volumine ex muris cellulae 6x on cytolytic activity of natural killer cells in vitro https://www.highdilution.org/index.php/ijhdr/article/view/1100 <p>Natural killer (NK) cells are among the first in defense of the innate immune system by eliminating a variety of abnormal or stressed cells such as cancer cells or virus-infected cells. Individuals who exhibit low cytolytic NK cell activity are believed to be at higher risk of viral infection, tumorigenesis, and various other diseases of the immune system. Therefore, restoration of impaired NK cell function might be an essential step in immunostimulatory therapy of immunocompromised patients. <em>Bacillus firmus</em> is a non-pathogenic gram-positive bacterium of the environment, which possesses various immunomodulatory properties <em>in vitro</em> and <em>in vivo</em>. This retrospective study reports on the effect of <em>B. firmus</em> on the activity of NK cells <em>in vitro</em>. Basal cytolytic NK cell activity against tumor cells among peripheral blood mononuclear cells (PBMCs) of routine patients was determined in a standardized NK cell cytotoxicity assay. The impact of cultivation of PBMCs with <em>B. firmus</em> preparation Bacillus firmus e volumine ex muris cellulae (Bacillus firmus (evc)) 6x on tumor cell killing by NK cells was monitored in relation to basal NK cell activity. This study showed that stimulation of PBMCs with Bacillus firmus (evc) 6x<em> in vitro</em> led to a significant increase in NK cell function. Substantial improvement in cytolytic NK cell activity (more than 1.3-fold of basal activity) was much more pronounced for patients with compromised NK cell function. Due to its immunostimulatory mode of action, Bacillus firmus (evc) may be of particular importance in therapy of patients with NK cell deficiency.</p> Dieter Sonntag Stephan Sudowe Copyright (c) 2021 Dieter Sonntag, Stephan Sudowe https://creativecommons.org/licenses/by-nc-sa/4.0 2021-07-22 2021-07-22 20 2-3 34 43 10.51910/ijhdr.v20i2-3.1100 An open-label, exploratory documentation of proving-symptoms of CVN01 (Coronavirus nosode from the clinical sample) in healthy volunteers https://www.highdilution.org/index.php/ijhdr/article/view/1073 <p><strong>INTRODUCTION </strong>Homeopathic Pathogenetic Trials (Proving) are human studies to examine the pathogenetic effects of investigational drugs in high dilution on healthy volunteers. As a part of the new coronavirus nosode development process for prophylactic use, the phase 1 study was conducted. The documentation of proving symptoms for a fast-track nosode development for a pandemic condition was the objectives of this study. <strong>MATERIALS AND METHODS </strong>An open-label trial to evaluate the safety and proving symptoms of Coronavirus nosode given orally to 10 volunteers (18-65 years age and of both the genders). Volunteers were administered 6 doses of nosode as 6 pills twice daily for 3 consecutive days. Pre and post examinations (physical), vital signs, and laboratory investigations, were done at day 0, 17, 34. Symptoms experienced by the volunteers were recorded. <strong>RESULTS </strong>Symptoms reported by volunteers were analyzed. The symptoms reported were mild to severe but reversible and matching with the symptoms produced by the viral infection. There were no serious/fatal adverse events during the study. The basic biochemistry and Liver Function tests were not affected by the Nosode. <strong>CONCLUSION </strong>New nosode developed during a pandemic condition produced certain symptoms in the homeopathic pathogenetic trial as a part of the Phase 1 study.</p> Rajesh Shah Gitanjali Talele Copyright (c) 2021 Rajesh Shah, Gitanjali Talele https://creativecommons.org/licenses/by-nc-sa/4.0 2021-07-22 2021-07-22 20 2-3 44 50 10.51910/ijhdr.v20i2-3.1073 Survey COVID-19 first peak 2020 - Viewpoint of Belgian Homeopathic Medical Doctors. https://www.highdilution.org/index.php/ijhdr/article/view/1062 This retrospective observational survey of the practice of Homeopathic Medical Doctors in Belgium including 313 patients presenting mild COVID-19 symptoms allows us to conclude that during such epidemic situation for which not any effective therapy exists and no vaccination is possible homeopathy should be considered. The efficiency score (healing of symptoms in less than 8 days) is relevant for 83,1% of these patients. 4 homeopathic medicines were prescribed to 66% of them. 1,3% needed hospitalization for some time. Not any loss of chance to cure occurred for these patients. Market data reveals that homeopathy has been largely used for prevention and healing during the early peak of COVID-19 in Belgium. Philippe Devos Paul Serneels Pablo Serneels Martine Goyens Michel Van Wassenhoven Copyright (c) 2021 Philippe Devos, Paul Serneels, Pablo Serneels, Martine Goyens, Michel Van Wassenhoven https://creativecommons.org/licenses/by-nc-sa/4.0 2021-07-22 2021-07-22 20 2-3 51 74 10.51910/ijhdr.v20i2-3.1062 Editorial https://www.highdilution.org/index.php/ijhdr/article/view/1108 Francisco Xavier Eizayaga Copyright (c) 2021 Francisco Xavier Eizayaga https://creativecommons.org/licenses/by-nc-sa/4.0 2021-07-22 2021-07-22 20 2-3 01 01 10.51910/ijhdr.v20i2-3.1108 Study of Germination Efficiency and Temperature/Drowning Resistance in some Ornamental Plants treated with Ultra High Dilute Compounds https://www.highdilution.org/index.php/ijhdr/article/view/1065 Background: The ultra-high dilutions (UHDs) can used for decreasing stress conditions causing by climate variations. Present research, it was investigated the effects of the ultra-high dilutions (UHDs) on some ornamental plants, germination, and hormonal variations. Methods: In order to study the effect of UHDs (Calendula officinalis Calen. and Arnica montana Arn.) on the physiological, primary metabolite and hormonal variations of the Oryza sativa L. (rice), 104 experiments were designed and statistically analyzed using the Design Expert 7.0.1 software over the general factorial design methodology. Two qualitative factors including the UHDs/placebo usage and the type of plant usage and two quantitative factors including temperature and irrigation were studied. The validated analysis was subjected to more extended studies on the variations in physiological growth, carbohydrate, protein content and levels of plants hormones including gibberellic acids, indole acetic acid, abscisic acid and salicylic acid. Results: The statistical analysis resulted in a prediction model which was more than 75% correlates with experimental results. The results showed that the UHDs increased the carbohydrate and protein content of seedlings. Also compared to placebo, the levels of hormones GA3 and IAA in all samples increase and the amount of GA4 decreases. The amount of ABA and SA hormones in S. officinalis increased under UHDs treatment while they decreased in the other two samples. Conclusion: The use of UHDs leads to an increase in the production of carbohydrate and protein content. Moreover, it causes significant variations in the growth inducing hormone and increase the tolerance of seeds under higher/lower temperature and draught/drowning. The results of this study open up a window to reduce the germination survival and increase their resistance to sudden climate change. Fateme Mirzajani Faeze Mirzajani Mitra Aelaei Copyright (c) 2021 Fateme Mirzajani, Faeze Mirzajani, Mitra Aelaei https://creativecommons.org/licenses/by-nc-sa/4.0 2021-07-22 2021-07-22 20 2-3 02 15 10.51910/ijhdr.v20i2-3.1065